glutathione - Overview

The most important molecule in your body

Why?

Detox

• we breathe in toxins in air
• we eat food with some toxins
• we drink fluids with some toxins

Robust levels of glutathione

• high in healthy cells
• low when cells are sick or die

Low glutathione levels in blood link to:

• high levels of HbA1c
  • hemoglobin oxidation
  • uncontrolled blood sugar levels
  • diabetes confirmation test HbA1c
• Parkinson′s diseases
• Alzheimer′s
• diabetes
• macular degeneration
• HIV (human immunodeficiency virus) disease

Active Immune system

• Nitric Oxide (NO-)
  • requires glutathione
  • Nitric Oxide keeps us healthy
• kills germs
  • viruses
  • bacteria
  • yeast, mold, fungi
  • parasites
• blood pressure control
  • low levels NO- is high bp
• fertility
  • when NO- is low
    • ED (male)
    • PCOS (female)
• Nitric Oxide is needed for bowel movements
  • low levels are constipation
  • along with hydration
• Glutathione releases nitric oxide
  • full health

How to say glutathione

• gloo″tah-thi´ōn
• glū'tă-thī'ōn
• glu-tah-thigh-own
• glutes and my thigh I own
• glu·ta·thi·one
• GSH

a tripeptide of glutamic acid, cysteine, and glycine;

the reduced form (GSH) serves as a reducing agent in many biochemical reactions,

being converted to oxidized glutathione (GSSG) in which

the cysteine residues of two glutathione molecules are connected by a disulfide bridge.

Reduced glutathione is important in protecting erythrocytes from oxidation and hemolysis;

deficiency causes sensitivity to oxidant drugs.

A tripeptide of glycine, l-cysteine, and l-glutamate,

with l-glutamate having an isopeptide bond with the amino moiety of l-cysteine.

Glutathione has a wide variety of roles in a cell;

it is the most prevalent non-protein thiol.

Glutathione disulfide (GSSG) consists of two glutathiones linked through a disulfide bridge;

the term oxidized glutathione for GSSG should be avoided because it includes the sulfones and sulfoxides.

(The term reduced glutathione is not necessary because glutathione is the thiol form.)

A deficiency of glutathione can cause hemolysis with oxidative stress.

It is also used in the course of intermediary metabolism as a donor of thiol (SH) groups and is essential for detoxification of acetaminophen.

See also: oxidized glutathione, reduced glutathione, glutathione reductase.

C10H17N3O6S, of glycine, cysteine, and glutamic acid

occurs widely in plant and animal tissues and is important in biological oxidation-reduction reactions.

glutathione A ubiquitous tripeptide with antioxidant activity involved in CNS metabolism,

serving as a coenzyme for some enzymes of

• oxidation-reduction systems,
• transmembrane amino acid transport,
• maintenance of red cell integrity
• prevention of H2O2 accumulation in red cells.

glutathione

γ-Glutamyl-cysteinyl-glycine

glutathione

protects red cells from oxidative damage

oxidative damage to red blood cells is elevated HbA1c

and, in the form of the enzyme glutathione peroxidase, plays an important role in detoxifying hydrogen peroxide and organic peroxides produced in the body. Glutathione also participates in the transport of amino acids from one cell to another.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
Glutathione
A molecule that acts as a co-enzyme in cellular oxidation-reduction reactions.
Mentioned in: Glucose-6-Phosphate Dehydrogenase Deficiency
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
glu·ta·thi·one (glū'tă-thī'ōn)
A tripeptide of glycine, l-cysteine, and l-glutamate; essential for detoxification of acetaminophen.
Medical Dictionary for the Dental Professions © Farlex 2012