Forms of glutathione

  1. GSH - Glutathione, reduced, G-SH, Sulfur+Hydrogen
  2. GSSG - Gutathione disulfide, glutathione bound to itself, non-reactive
  3. GSNO - Nitrosglutathione , G-S-NO, Sulfur+Nitric Oxide



Nitrosglutathione (GSSG)

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S-Nitrosoglutathione (GSNO) is an endogenous S-nitrosothiol (SNO) that plays a critical role in nitric oxide (NO) signaling and is a source of bioavailable NO.

GSNO in Health and Disease

GSNO and NO concentrations regulate respiratory function by modulating airway tone and pro- and anti-inflammatory responses in the respiratory tract.[14][15] Because NO is a labile gas and endogenous levels are difficult to manipulate, it has been proposed that exogenous GSNO could be used to regulate circulating levels of NO and NO-derived species, and GSNO could have value in patients with pulmonary diseases such as cystic fibrosis. Consistent with this therapeutic goal, a recent study showed that acute treatment with aerosolized GSNO was well tolerated by cystic fibrosis patients.[14]

SNOs in the hepatic mitochondria appear to influence proper functioning of the liver.

---------- disulfide


  • R−S−S−R′
  • SS-bond or sometimes a disulfide bridge
  • usually derived by the coupling of two thiol groups


  • R-S-S-R
  • thiol means sulfur
  • cysteine is a single SH, (sulfur hydroxyl)
  • disulfide, two cysteine residues
  • important in structure of proteins
  • persulfide, R−S−S−H compounds, note Hydrogen at the end