4 major types of lipids in membranes
- PC - phospahtidylcholine (PtdCho)
- PE - phosphatidylethanolamine (PtdEtn)
- SM - sphingomyelin
- Cholesterol - (HDL-C)
Notes:
- cholesterol (HDL-C) is not to be confused with ergosterol (LDL-C)
- SM contains C:22 whereas a yeast contains C:26 fatty acid + manose sugar**
- Ref: **https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642958/
- SM and HDL-C are key to myelin function in memory
- we are born with little myelin and it is laid down as we learn to coordinate; crawl, language, walk.
- myelin interacts with sulfur to allow replacement of single lipids and preserve memory
- sulfur declines as we age but is only a small part of our total makeup
There are thousands of combinations of these 4 lipids.
- Combinations affect membrane function
- Oxygen end of fatty acids are fluid friendly
- Proteins embed to further membrane interactions
- Proteins can become channels of transfer
- calcium, sodium, potassium channels
- temporary sensory stimulation; Transient Receptor Potential - TRP,
- receptors sites
- insulin
- steroids
- other signaling molecules
- Fragments of membrane are also involved in signalling
- damaged PC membranes release an omega-6 lipid
- stimulates inflammatory response
- signals to platlets to engage, stick
- constricts arteries
- coagulates leaking blood
- prevents hemorrhage and death.